Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development
Identifieur interne : 000564 ( 2020/Analysis ); précédent : 000563; suivant : 000565Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development
Auteurs : Ruklanthi De Alwis [Singapour] ; Shiwei Chen [Singapour] ; Esther S. Gan [Singapour] ; Eng Eong Ooi [Singapour]Source :
- EBioMedicine [ 2352-3964 ] ; 2020.
Abstract
The pandemic spread of a novel coronavirus – SARS coronavirus-2 (SARS-CoV-2) as a cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of many countries under unprecedented stress. Global economies are also spiraling towards a recession in fear of this new life-threatening disease. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. However, both hyperimmune globulin and vaccine development face a common hurdle – the risk of antibody-mediated disease enhancement. The goal of this review is to examine the body of evidence supporting the hypothesis of immune enhancement that could be pertinent to Covid-19. We also discuss how this risk could be mitigated so that both hyperimmune globulin and vaccines could be rapidly translated to overcome the current global health crisis.
Url:
DOI: 10.1016/j.ebiom.2020.102768
PubMed: NONE
PubMed Central: 7161485
Affiliations:
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Global economies are also spiraling towards a recession in fear of this new life-threatening disease. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. However, both hyperimmune globulin and vaccine development face a common hurdle – the risk of antibody-mediated disease enhancement. The goal of this review is to examine the body of evidence supporting the hypothesis of immune enhancement that could be pertinent to Covid-19. We also discuss how this risk could be mitigated so that both hyperimmune globulin and vaccines could be rapidly translated to overcome the current global health crisis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Guan, W J" uniqKey="Guan W">W.J. 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Ma</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="De Alwis, Ruklanthi" sort="De Alwis, Ruklanthi" uniqKey="De Alwis R" first="Ruklanthi" last="De Alwis">Ruklanthi De Alwis</name></noRegion><name sortKey="Chen, Shiwei" sort="Chen, Shiwei" uniqKey="Chen S" first="Shiwei" last="Chen">Shiwei Chen</name><name sortKey="De Alwis, Ruklanthi" sort="De Alwis, Ruklanthi" uniqKey="De Alwis R" first="Ruklanthi" last="De Alwis">Ruklanthi De Alwis</name><name sortKey="Gan, Esther S" sort="Gan, Esther S" uniqKey="Gan E" first="Esther S." last="Gan">Esther S. Gan</name><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng Eong" last="Ooi">Eng Eong Ooi</name><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng Eong" last="Ooi">Eng Eong Ooi</name><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng Eong" last="Ooi">Eng Eong Ooi</name><name sortKey="Ooi, Eng Eong" sort="Ooi, Eng Eong" uniqKey="Ooi E" first="Eng Eong" last="Ooi">Eng Eong Ooi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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